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Prof. Dr. Ralf Enz

Institut für Biochemie
Fahrstrasse 17
91054 Erlangen 
 
Phone (+49) 9131 85 26205
Fax (+49) 9131 85 22485

Ralf.Enz@biochem.uni-erlangen.de
http://www.biochem.uni-erlangen.de/
http://www.biochem.uni-erlangen.de/forschung/arbeitsgruppe.php?arbeitsgruppe=26

Research areas:

Structure and function of synaptic signal complexes in the mammalian retina 

The correct targeting of ion channels and neurotransmitter receptors to synapses, as well as the adequate regulation of these receptors by interacting partners represent the basis for the precise regulation of neuronal networks. Synaptically localized macromolecular signal complexes are important mediators of these mechanisms. These protein complexes cross-link ion channels, receptors, enzymes and scaffold proteins at pre- or post-synaptic specializations, and in addition are anchored to the synaptic cytoskeleton. Malfunction of these complexes can lead to impaired signal transduction and ultimately may cause neurodegenerative processes. To elucidate molecular mechanisms of neuronal signal transduction we identify and characterize intracellular binding partners of GABA and glutamate receptors in the mammalian retina. Applied techniques include molecular biology and biochemistry, cell culture, anatomy, electrophysiology and bioinformatics.