Prof. Dr. Martin Fromm

Institut für Experimentelle und Klinische Pharmakologie und Toxikologie
Lehrstuhl für Klinische Pharmakologie und Klinische Toxikologie
Friedrich-Alexander-Universität Erlangen-Nürnberg
Fahrstr. 17
91054 Erlangen

ph. +49 (0)9131 85-22772
FAX +49 (0)9131 85-22773

Research areas:

In spite of the correct use of drugs, a significant proportion of the patients has no adequate drug effect or suffers from drug toxicity. This variability in drug effects can be due to genetic or environmental (e.g. nutrition, comedication) factors. The goal of our group is to help to get a better understanding of the causes for interindividual differences in drug effects and to further optimize drug treatment.

It is now well established that many drugs are translocated through cell membranes via different transporter proteins. In addition to drug transport, metabolism is also an important determinant of drug disposition and effects. Our research focusses on the following topics:

- Drug transporter (OATPs, OCTs, BCRP, P-glycoprotein, MRPs)

- Intestinal and hepatic drug metabolism

- Pharmacogenomics