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Prof. Dr. Michael Wegner

Lehrstuhl für Biochemie und Pathobiochemie
Institut für Biochemie
Emil-Fischer-Zentrum
Fahrstrasse 17
91054 Erlangen

09131 85 24620
09131 85 22484

m.wegner@biochem.uni-erlangen.de
http://www.biochem.uni-erlangen.de/forschung

Research areas:

Glial cells and neurons arise from the same pool of neuroectodermal stem cells. Whether a cell becomes a glial cell or a nerve cell is determined early in development. After the initial determination event cells continue to proliferate for some time, before they finally undergo terminal differentiation. My group is interested in the identification and characterization of transcriptional regulators that participate in determination and differentiation of neural, in particular glial cells in the developing mammalian nervous system. We focus on POU domain proteins and on Sox proteins. Analysis of these transcription factors will lead to a better understanding of developmental defects, tumor formation and regenerative processes in the nervous system.